Going back to 1980, this will only be the 4th coaster removed from CP (or 3rd if you don't consider the Mean Streak -> Steel Vengeance transformation to be a true removal).
- Wildcat's removal in 2011 did not lead to a direct coaster replacement.
- Disaster Transport's removal in 2012 cleared the way for Gatekeeper in 2013.
- And of course the aforementioned RMC'ing of Mean Streak from 2016 - 2018.
My gut tells me that WT's departure will lead to a coaster replacement, but I could certainly be wrong.
How likely would Cedar Point be to remain competitive for the title of most coasters in a park? With a current count of 17 coasters, they're tying a third place between SFMM (19) and Energylandia (18). I doubt they're likely to replace Wicked Twister with four new coasters to take the title, but they could still be hesitant to reduce their coaster numbers by removing a coaster without replacing it. I mean, for marketing purposes it could be important for them to stay near the top of the list even if they don't top it.
And if we're allowed to speculate on what will replace it, I daresay a coaster is fairly likely. With the removal of Wicked Twister, the stadium, and a tower ride in the area, they have cleared a quite long and thin piece of land. Perfect for a coaster with a compact footprint, not very useful for most other things.
I wonder if they will finally go for something outside of the white-knuckle thrill category, though. The last time they built something RCDB doesn't classify as "Extreme" was Woodstock Express in 1999, and before that it was Iron Dragon in 1987. Their most recent coaster that doesn't feature an inversion is Top Thrill Dragster from 2003. A coaster like Ice Breaker would be a nice stepping stone between their family-sized coasters and the big thrill machines. As Woodstock Express is a lowly family coaster, Cedar Point's most recent coaster in the "stepping stone"/"little thrill" category is more than thirty years old, and the three others in the park are even older. I would say that's the weakest aspect of the park's current coaster lineup at the moment, and where it would be logical to put in some resources. Not only are the current Thrill coasters old enough that spare parts might become an issue (although at least some of them might have crossed the treshold between "old and rickety" and "historic" so the park may put in the required effort to preserve them), but a lot has also happened on the development front of such coasters since the late 1980's. Not to mention the lack of any aparent holes in the extreme coaster lineup. If Cedar Point went for such a coaster, what could they reasonably go for?